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Reproducible TCGA-LUAD survival pipeline on RNA-seq, clinical and mutation data. LASSO-Cox gene signature overfit (train C=0.722, test 0.538), reported as a negative finding; clinical Cox model (age, sex, grouped stage) validated on external cohort GSE31210 (C=0.708). Snakemake, Docker, FastAPI.

  • Updated Sep 26, 2026
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